suēle | Evidence Library
The Latest Research
on Red Light Therapy
Curated peer reviewed studies for each therapeutic benefit with direct links to the source publications.
For informational purposes only. Not medical advice.
Skin Rejuvenation
660nm | Red LightA Controlled Trial to Determine the Efficacy of Red and Near Infrared Light Treatment in Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase
Photomedicine and Laser Surgery, 2014
136 volunteers received red or near infrared light twice weekly for 30 sessions. Treated groups showed significant improvements in skin complexion, skin roughness, and intradermal collagen density compared to controls with no adverse effects reported.
Photobiomodulation Reduces Periocular Wrinkle Volume by 30%: A Randomized Controlled Trial
Photobiomodulation, Photomedicine, and Laser Surgery, 2023
137 women aged 40 to 65 received 10 sessions of 660nm red LED over 4 weeks in a split face design. Periocular wrinkle volume was measured objectively by VisioFace equipment. Red light produced a significant measurable reduction in wrinkle volume together with improvements in hydration and elasticity.
Reverse Skin Aging Signs by Red Light Photobiomodulation
Skin Research and Technology, 2023
Participants received twice weekly red LED sessions at 630nm. Wrinkle appearance, skin firmness, and overall photoaging scores were assessed before and after treatment. Results showed statistically significant improvement across multiple visible aging markers including fine lines, uneven tone, and firmness.
Muscle Recovery
850nm | Near InfraredPhotobiomodulation Therapy PBMT and or Cryotherapy in Skeletal Muscle Restitution: What Is Better? A Randomized Double Blinded Placebo Controlled Clinical Trial
Photomedicine and Laser Surgery, 2016
50 healthy males were randomised to PBMT, cryotherapy, combined therapy, or placebo after eccentric exercise. Muscle performance, soreness, and creatine kinase were assessed at multiple time points up to 96 hours after exercise. PBMT alone outperformed all other groups across every marker.
Effects of Photomodulation Therapy for Delayed Onset Muscle Soreness: A Systematic Review and Meta Analysis
Journal of Functional Morphology and Kinesiology, 2025
14 controlled studies were analysed across wavelengths from 660 to 950nm for delayed onset muscle soreness. The meta analysis found moderate to large effects for reducing soreness and improving strength recovery after eccentric exercise with photomodulation therapy consistently outperforming placebo.
Differences in the Effectiveness of Physical Therapy Modalities for Delayed Onset Muscle Soreness: A Systematic Review and Bayesian Network Meta Analysis
PMC / Frontiers, 2024
15 RCTs compared 9 physical therapy modalities for delayed onset muscle soreness. PBMT ranked first at 24 hours and 48 hours after exercise. At 24 hours PBMT showed the strongest pain reduction of all modalities when compared with placebo.
Joint & Pain Relief
850nm | Near InfraredThe Mechanisms and Efficacy of Photobiomodulation Therapy for Arthritis: A Comprehensive Review
International Journal of Molecular Sciences, 2023
This review summarises animal and clinical evidence for photobiomodulation in rheumatoid arthritis and osteoarthritis. Five core therapeutic mechanisms are identified including ATP support, angiogenesis regulation, and cytokine modulation with evidence from both cell level and clinical studies.
Efficacy of Photobiomodulation Therapy in the Treatment of Pain and Inflammation: A Literature Review
Journal of Clinical Medicine, 2023
A systematic review of 11 RCTs from 2017 to 2022 assessed photobiomodulation for chronic musculoskeletal pain in adults. Seven studies measured pain scores directly. The review found consistent reductions in pain intensity and inflammatory markers across tendinopathy, joint pain, and myofascial conditions.
Effects of Photobiomodulation on Multiple Health Outcomes: An Umbrella Review of Randomized Clinical Trials
PMC / Frontiers, 2025
15 meta analyses covering more than 9,000 patients assessed 35 health endpoints. Joint related conditions including knee osteoarthritis, rheumatoid arthritis, plantar fasciitis, tendinopathy, and Achilles tendinopathy were among the positive outcome categories reported across the reviewed literature.
Better Sleep
660nm + 850nmEffect of Whole Body Red Light Therapy on Sleep Quality and Endurance Performance in Female Basketball Players
Journal of Athletic Training, 2012
21 healthy female athletes received 30 minutes of whole body red light treatment nightly for 14 nights. Sleep quality, serum melatonin, and endurance performance were assessed. The treatment group showed significant improvements across all 3 measures compared with the sham group.
Brain Photobiomodulation Improves Sleep Quality in Subjective Cognitive Decline: A Randomized Sham Controlled Study
Journal of Alzheimer's Disease, 2022
58 participants with subjective cognitive decline received prefrontal cortex photobiomodulation for 6 consecutive days. Objective sleep efficiency and working memory performance were measured daily. Both improved significantly in the treatment group compared with sham and the effects were measurable by day 5.
Enhancing Sleep Wakefulness and Cognition with Transcranial Photobiomodulation: A Systematic Review
Frontiers in Behavioral Neuroscience, 2025
This systematic review summarises transcranial photobiomodulation studies across sleep and wakefulness outcomes. Identified mechanisms include pineal gland melatonin support, reduced neuroinflammation, and improved sleep architecture with positive findings across healthy athletes, anxiety disorders, and people with cognitive decline.
Cognitive Function
850nm | Near InfraredTranscranial Photobiomodulation Increases Cognition and Serum BDNF Levels in Adults Over 50 Years: A Randomized Double Blind Placebo Controlled Trial
Journal of Photochemistry and Photobiology B, 2024
93 adults with mild cognitive impairment were randomised to whole head near infrared LED photobiomodulation or placebo for 60 days. Cognitive scores, BDNF levels, and neurodegeneration markers were assessed at baseline, 60 days, and 150 day follow up. The treatment group showed significant improvements in cognitive scores and BDNF.
Can Transcranial Photobiomodulation Improve Cognitive Function? A Systematic Review of Human Studies
Ageing Research Reviews, 2022
35 human studies on transcranial photobiomodulation for cognitive function were reviewed across learning, memory, attention, and executive function in healthy adults, people with mild cognitive impairment, traumatic brain injury, and dementia. 29 of 35 studies reported positive cognitive improvements with every mild cognitive impairment and dementia study showing benefit.
Brain Photobiomodulation Improves Sleep Quality in Subjective Cognitive Decline
Journal of Alzheimer's Disease, 2022
This sham controlled randomized trial found that prefrontal photobiomodulation significantly improved working memory within 5 days in addition to the sleep improvements reported in the same trial.
Improved Circulation
660nm + 850nmLow Level Laser Light Therapy LLLT for Treatment of Hair Loss: Nitric Oxide and Vascular Mechanisms
Lasers in Surgery and Medicine, 2014
This mechanism focused review describes a key vascular pathway. Low level light therapy can cause photodissociation of nitric oxide from cytochrome c oxidase and intracellular haemoglobin stores. The released nitric oxide acts as a vasodilator through cGMP signalling which may increase local blood flow and oxygen delivery.
Transcranial Photobiomodulation for Brain Diseases: Review of Animal and Human Studies Including Mechanisms and Emerging Trends
PMC, 2024
This review reports that transcranial photobiomodulation at 808nm increased cerebral blood flow by 30% in the illuminated hemisphere and 19% in the opposite hemisphere during a 45 minute session. The proposed mechanism involves nitric oxide synthase activity and increased cortical nitric oxide concentration reported in human investigations.
Unlocking the Power of Light on the Skin: A Comprehensive Review on Photobiomodulation
International Journal of Molecular Sciences, 2024
This dermatology focused review describes how photobiomodulation may activate fibroblast growth factor, increase tissue oxygenation, and support circulation through multiple vascular pathways. LED and near infrared light may also help reduce oxidative stress in vessel walls.
Reduced Inflammation
660nm + 850nmEffects of Photobiomodulation on Multiple Health Outcomes: An Umbrella Review of Randomized Clinical Trials
PMC / Frontiers, 2025
15 meta analyses covering more than 9,000 patients and 35 health endpoints reported anti inflammatory outcomes across rheumatoid arthritis, fibromyalgia, temporomandibular disorders, tendinopathy, and knee osteoarthritis.
Efficacy of Photobiomodulation Therapy in the Treatment of Pain and Inflammation: A Literature Review
Journal of Clinical Medicine, 2023
A systematic review of 11 RCTs for chronic musculoskeletal inflammation found that 7 studies directly showed reductions in subjective pain and objective inflammatory markers. This supports both pain relief and anti inflammatory action.
Unlocking the Power of Light on the Skin: A Comprehensive Review on Photobiomodulation
International Journal of Molecular Sciences, 2024
This review describes molecular pathways through which photobiomodulation may reduce inflammation including lower MMP expression, reduced reactive oxygen species, lower pro inflammatory interleukin activity, and transcription factor modulation.
Hair Growth
660nm | Red LightLow Level Laser Therapy for Androgenetic Alopecia in Thai Men and Women: A 24 Week Randomized Double Blind Sham Device Controlled Trial
Lasers in Medical Science, 2019
A 24 week double blind trial assessed a helmet type light therapy device at 655nm in men and women with androgenetic alopecia. Hair density, hair diameter, and global photographic assessment were measured by blinded investigators. The device performed significantly better than sham on both primary outcomes.
The Growth of Human Scalp Hair Mediated by Visible Red Light Laser and LED Sources in Males
Lasers in Surgery and Medicine, 2014
44 males with androgenetic alopecia used an active 655nm light therapy device or placebo at home every other day for 16 weeks. Hair counts were performed by a blinded investigator. The active group showed a significant improvement in hair counts compared with placebo.
Comparative Effectiveness of Low Level Laser Therapy for Adult Androgenic Alopecia: A Systematic Review and Meta Analysis of RCTs
Lasers in Medical Science, 2019
This meta analysis of randomized trials compared light therapy with sham for androgenetic alopecia across wavelengths from 630 to 808nm. Quantitative analysis confirmed significantly increased hair density across both sexes, across different device types, and across short and long treatment durations.